General Cell Based Assays
Eurofins Discoverx PathHunter eXpress CALCR-RAMP2 (AMY2) CHO-K1 β-Arrestin GPCR Assay, 2pl Kit. (93-0267E2CP0M)
The PathHunter CALCR-RAMP2 (AMY2) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. calcitonin) based activation of CALCR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CALCR and EA-tagged β-Arrestin-2, along with untagged modulating protein RAMP2. Activation of CALCR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery U-PLEX Human SDF-1 ASY
The Meso Scale Discovery U-PLEX Human SDF-1alpha Assay Kit is a multiplex immunoassay that measures SDF-1alpha levels in human serum plasma and cell culture supernatants The assay uses electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and requires low sample volume The kit includes a 96-well plate coated with capture antibodies detection antibodies labeled with ruthenium calibrators and reagents needed to run the assay Results are obtained in as little as 3 5 hours This assay allows for the quantitative measurement of SDF-1alpha levels for life science research applications
Eurofins Discoverx PathHunter eXpress CCR4 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0193E2CP0L)
The PathHunter CCR4 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL22/MDC) based activation of CCR4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCR4 and EA-tagged β-Arrestin-2. Activation of CCR4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter TrkC Bioassay Kit, 10-Plate. (93-0464Y3-00078)
The PathHunter TrkC Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This cell line enables assessment of ligand (e.g. NT-3) based activation of TrkC receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged TrkC target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Meso Scale Discovery U-PLEX Mouse IL-15 ASY 25 PL
The Meso Scale Discovery U-PLEX Mouse IL-15 Assay Kit is an electrochemiluminescent immunoassay for the quantitative measurement of mouse interleukin 15 (IL-15) in serum plasma and cell culture supernatants The assay uses MSD s proprietary SULFO-TAG labels and multi-array technology to provide sensitive and reproducible quantitation of mouse IL-15 with a lower limit of detection of 1 3 pg/mL and an upper limit of quantification of 10 000 pg/mL The kit includes a 96-well plate coated with capture antibody detection antibody conjugated to MSD SULFO-TAG calibrators and sample diluent The assay takes approximately 3 5 hours to complete after a 2 hour incubation
Eurofins Discoverx PathHunter eXpress GPR132 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0411E2ACP1M)
The PathHunter GPR132 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR132 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR132 and EA-tagged β-Arrestin-2. Activation of GPR132 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human AVPR2 (S167T) ENDO-EA Pharmacotrafficking Cell-Based Assay Kit (U2OS)
The PathHunter Human AVPR2 (S167T) ENDO-EA Pharmacotrafficking Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure pharmacochaperone-based rescue of the mutant AVPR2's trafficking to early endosomes. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human FPR1 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human FPR1 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure FPR1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human Heregulin beta 1 (ErbB2/ErbB4) Dimerization Cell-Based Assay Kit (U2OS)
The PathHunter Human Heregulin beta 1 (ErbB2/ErbB4) Stable Cell Line Dimerization Assay (U2OS) measures ligand-induced dimerization of ErbB2/ErbB4. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human GLP-1 (GLP-1 Receptor) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human GLP-1 (GLP1R) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure GLP1R (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human GALR1 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human GALR1 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure GALR1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human SCTR β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human SCTR β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure SCTR (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Abcam Cell Tracking Dye Kit - Orange - Cytopainter
Cell Tracking Dye Kit - Orange - Cytopainter
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical 8-cPeT NAD sodIum salt 800ug
A derivative of NAD+; has been used in the screening of analog-sensitive PARP1 gatekeeper mutations
Eurofins Discoverx PathHunter Mouse P2RY6 β-Arrestin Cell-Based Assay Kit (U2OS)
The PathHunter Mouse P2RY6 β-Arrestin Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure mP2RY6 (GPCR) activity via recruitment of β-Arrestin2. Mouse protein. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.